Investigator(s)
| Submitter |
Namkha Dorji Consultant Gynecological Oncologist and Obstetrician, JDWNRH Assistant Professor, FoPGM, KGUMSB Namkha Dorji 
|
| Principal Investigator |
Namkha Dorji Consultant Gynecological Oncologist and Obstetrician, JDWNRH Assistant Professor, FoPGM, KGUMSB Namkha Dorji
|
| Co-Investigator(s) |
Yeshey Dorjey Department of Obstetrics and Gynecology, Eastern Regional Referral Hospital, Mongar, Bhutan. Yeshey Dorjey
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| Co-Investigator(s) |
Dago Dem Wangdue District Hospital, Wangdiphodrang Dago Dem
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| Co-Investigator(s) |
Tandin Om Department of Obstetrics and Gynecology, Central Regional Referral Hospital, Gelephu, Sarpang, Bhutan. Tandin Om
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| Co-Investigator(s) |
Sonam Wangmo Obstetrics and Gynecology Unit, Phuntsholing General Hospital, Chukha, Bhutan Sonam Wangmo
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| Co-Investigator(s) |
Dorji Wangchuk Obstetrics and Gynecology Unit, Phuntsholing General Hospital, Chukha, Bhutan Dorji Wangchuk
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| Co-Investigator(s) |
Deep Kiran Chhetri Obstetrics and Gynecology Unit, Trashigang Cluster Hospital, Trashigang, Bhutan Deep Kiran Chhetri
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| Co-Investigator(s) |
Chuni Seldon Military Hospital, Lungtenphu, Thimphu, Bhutan Chuni Seldon
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| Co-Investigator(s) |
Namgay Choden Military Hospital, Lungtenphu, Thimphu, Bhutan Namgay Choden
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| Co-Investigator(s) |
Sonam Choden Department of Pathology and Laboratory Medicine, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan Sonam Choden
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| Co-Investigator(s) |
Jigme Jamtsho Department of Pathology, Central Regional Referral Hospital, Gelephu, Sarpang, Bhutan. Jigme Jamtsho
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| Co-Investigator(s) |
Karma Lhaden Department of Obstetrics and Gynecology, Gyaltshuen Jetsun Pema Mother and Child Hospital, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan. Karma Lhaden
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| Co-Investigator(s) |
Sonam Yuden Department of Obstetrics and Gynecology, Gyaltshuen Jetsun Pema Mother and Child Hospital, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan. Sonam Yuden
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| Co-Investigator(s) |
Tshering Wangden Department of Obstetrics and Gynecology, Gyaltshuen Jetsun Pema Mother and Child Hospital, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan. Tshering Wangden
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| Co-Investigator(s) |
Damanti Bhujel Colposcopy Clinic, Gyaltshuen Jetsun Pema Mother and Child Hospital, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan Damanti Bhujel
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| Co-Investigator(s) |
Meera Chhetri Colposcopy Clinic, Gyaltshuen Jetsun Pema Mother and Child Hospital, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan Meera Chhetri
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| Co-Investigator(s) |
Sonam Wangchuk National Cancer Control Program, Ministry of Health, Thimphu, Bhutan. Sonam Wangchuk
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| Co-Investigator(s) |
Yangdon Yangdon National Cancer Control Program, Ministry of Health, Thimphu, Bhutan. Yangdon Yangdon
|
Title(s) and abstract
| Scientific title | Performance of colposcopy in the diagnosis of histologic cervical intraepithelial neoplasia 2+ (CIN2+) in Bhutan: a multi-centre cross sectional study. |
| Public title | The accuracy of colposcopy to diagnose CIN2+ |
| Background | In Bhutan, cervical cancer is the most common gynaecological cancer and leading cause of death from gynaecological cancers. HPV DNA testing has replaced conventional pap smear in 2020 for the national cervical cancer screening method. In cases of positive HPV-DNA result, colposcopy is an important procedure where it helps in localising the anatomical site of suspicious lesions. Then biopsies are taken for confirmation of diagnosis by histopathology examination. Several quality improvement initiatives on colposcopy have been undertaken in Bhutan. In this study, we aim to assess the performance of colposcopy in the diagnosis of histopathologic CIN 2+ in Bhutan. |
| Objectives | The aim of this study is to assess the performance of colposcopy in the diagnosis of histopathologic CIN 2+ and margin positivity of LEEP specimens in Bhutan. |
| Study Methods | This will be a cross-sectional study conducted across Bhutan in seven colposcopy centres namely Jigme Dorji Wangchuck National Referral Hospital (JDWNRH), Eastern Regional Referral Hospital (ERRH), Central Regional Referral Hospital (CRRH), Trashigang Cluster Hospital (TCH), PGH, Lungtenphu Army Hospital and Wangdue hospital. Sociodemographic data will be collected using a standard pro forma; information on HPV-DNA and histopathology results will be extracted from the Department of Pathology, JDWNRH, ERRH and CRRH using the unique citizenship identity card number of study participants. The colposcopy details will be directly entered by the colposcopist at the time of colposcopy. Ethics approval will be sought from the Research Ethics Board of Bhutan; administrative approval from the Ministry of Health and the Hospital Administration from the respective hospitals. Data will be entered into EpiData 3.1 (Odense, Denmark) and will be analyzed using STATA 13.1 |
| Expected outcomes and use of results | The socio-demographic and clinical variables of the participants will be presented. Sensitivity, specificity, positive and negative predictive values of colposcopy and the margin positivity of the LEEP specimen will be presented. |
| Keywords | Colposcopy, cervical intraepithelial neoplasia, cervical pre-cancer, Loop electrosurgical excision procedure, LEEP, Cervical cancer. |
Research Details
| Student research | No |
| Start Date | 30-Jan-2026 |
| End Date | 29-Jul-2026 |
| Key Implementing Institution | Jigme Dorji Wangchuck National Referral Hospital |
| Multi-country research | No |
| Nationwide research | Yes |
| Research Domain(s) | Non-communicable diseases & Healthy Lifestyles |
| Research field(s) | Other (Cancer) |
| Involves human subjects | Yes |
| Operational Research | |
| Data Collection | Primary data |
| Proposal reviewed by other Committee | No |